Medoff started as a brewer at McMenamins and co-founded House Spirits before starting Bull Run Distillery. Lee is the founder and head distiller of Bull Run Distillery in Portland, Oregon.

He started House Spirits Distillery in 2004, where he helped create several popular craft spirit brands of which his namesake Medoyeff Vodka and Aviation Gin are the most successful. He was one of the founding members and first president of the Oregon Distillers Guild, America’s first craft distillers guild. In 2010, with his sights set on making a pure malt Oregon Whiskey, he started Bull Run Distillery. It is here that he focuses on creating dark, aged spirits, from rum made with Hawaiian cane sugar to many expressions of whiskey.